Understanding allosteric modulation and biased signalling at Family B GPCRs

Project: Research

Status	Finished
Effective start/end date	1/01/15 → 31/12/18

Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists
Fletcher, M. M., Halls, M. L., Zhao, P., Clydesdale, L., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Oct 2018, In: Biochemical Pharmacology. 156, p. 406-419 14 p.
Research output: Contribution to journal › Article › Research › peer-review

44 Citations (Scopus)
Coexpressed class B G protein-coupled secretin and GLP-1 receptors self- and cross-associate: impact on pancreatic islets
Harikumar, K. G., Lau, S., Sexton, P. M., Wootten, D. & Miller, L. J., 1 Jun 2017, In: Endocrinology. 158, 6, p. 1685-1700 16 p.
Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)
Phase-plate cryo-EM structure of a class B GPCR-G-protein complex
Liang, Y.-L., Khoshouei, M., Radjainia, M., Zhang, Y., Glukhova, A., Tarrasch, J., Thal, D., Furness, S. G. B., Christopoulos, G., Coudrat, T., Danev, R., Baumeister , W., Miller, L. J., Christopoulos, A., Kobilka, B., Wootten, D., Skiniotis, G. & Sexton, P., 1 Jun 2017, In: Nature. 546, 7656, p. 118-123 6 p.
Research output: Contribution to journal › Article › Research › peer-review

398 Citations (Scopus)

Project Details