Translating membrane proteins into therapeutics; from bedside to bench

Project: Research

Status	Finished
Effective start/end date	1/01/19 → 31/12/23

Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein
Cao, J., Belousoff, M. J., Danev, R., Christopoulos, A., Wootten, D. & Sexton, P. M., 7 May 2024, In: Biochemistry. 63, 9, p. 1089-1096 8 p.
Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)
Importance of receptor expression in the classification of novel ligands at the M₂ muscarinic acetylcholine receptor
Jiang, Y., Yeasmin, M., Gondin, A. B., Christopoulos, A., Valant, C., Burger, W. A. C. & Thal, D. M., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2338-2350 13 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

8 Citations (Scopus)
Ligand-directed biased agonism at human histamine H₃ receptor isoforms across Gα_i/o- and β-arrestin2-mediated pathways
Rahman, S. N., Imhaouran, F., Leurs, R., Christopoulos, A., Valant, C. & Langmead, C. J., Oct 2024, In: Biochemical Pharmacology. 228, 24 p., 115988.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

2 Citations (Scopus)

Project Details