Transformative rat models to study sex differences in disease

  • Arnold, Art (Primary Chief Investigator (PCI))
  • Eghbali, Mansoureh (Chief Investigator (CI))
  • Dwinell, Melinda R. (Chief Investigator (CI))
  • Geurts, Aron (Chief Investigator (CI))
  • Harley, Vincent (Chief Investigator (CI))
  • Sandberg, Kathryn (Chief Investigator (CI))
  • O'Donnell, Liza (Chief Investigator (CI))
  • Browne, Janelle (Chief Investigator (CI))

Project: Research

Project Details

Project Description

This proposal is to develop a transformational transgenic rat model (“Four Core Genotypes”) to measure the differential effects of XX and XY sex chromosomes in any rat model of physiology and disease. Most diseases show sex differences in incidence or progression, which implies that one sex has biological factors that protect from or exacerbate disease, relative to the other sex. Understanding the mechanisms of protection / vulnerability will be valuable if it identifies new therapeutic targets. Moreover, understanding sex differences makes biomedical research relevant to the entire population, and enhances reproducibility and rigor.
Effective start/end date15/06/2131/03/24


  • NIH - National Institutes of Health (United States of America): A$4,383,784.18