Project Details
Project Description
Nuclear proteins hold the key to unlocking the information held in our DNA. Activated STAT3 is a protein that enters the nucleus to direct the expression of new gene products, and can be persistently activated in heart disease and cancer. This project addresses how STAT3's time of residence in the nucleus is regulated and how this impacts on its ability to drive gene expression through specific modulation of microRNA molecules. Results will provide new insights into gene expression with applications in biology and biomedicine.
| Status | Finished |
|---|---|
| Effective start/end date | 3/01/13 → 31/12/16 |
Funding
- ARC - Australian Research Council: A$360,000.00
- Monash University
Research output
- 5 Article
-
Oligonucleotide-directed STAT3 alternative splicing switch drives anti-tumorigenic outcomes in MCF10 human breast cancer cells
Tano, V., Jans, D. A. & Bogoyevitch, M. A., 11 Jun 2019, In: Biochemical and Biophysical Research Communications. 513, 4, p. 1076-1082 7 p.Research output: Contribution to journal › Article › Research › peer-review
11 Link opens in a new tab Citations (Scopus) -
Quantifying the dynamics of the oligomeric transcription factor STAT3 by pair correlation of molecular brightness
Hinde, E., Pandzic, E., Yang, Z., Ng, I. H. W., Jans, D. A., Bogoyevitch, M. A., Gratton, E. & Gaus, K., 24 Mar 2016, In: Nature Communications. 7, 14 p., 11047.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile36 Link opens in a new tab Citations (Scopus) -
Cytokine-induced slowing of STAT3 nuclear import; faster basal trafficking of the STAT3 beta isoform
Ng, I. H. W., Bogoyevitch, M. A. & Jans, D. A., 2014, In: Traffic. 15, 9, p. 946 - 960 15 p.Research output: Contribution to journal › Article › Research › peer-review
15 Link opens in a new tab Citations (Scopus)