Transcription Factor Nuclear Residency As A Driver of Gene Expression

  • Jans, David (Primary Chief Investigator (PCI))
  • Bogoyevitch, Marie Ann (Chief Investigator (CI))
  • Goodall, Gregory (Chief Investigator (CI))

Project: Research

Project Details

Project Description

Nuclear proteins hold the key to unlocking the information held in our DNA. Activated STAT3 is a protein that enters the nucleus to direct the expression of new gene products, and can be persistently activated in heart disease and cancer. This project addresses how STAT3's time of residence in the nucleus is regulated and how this impacts on its ability to drive gene expression through specific modulation of microRNA molecules. Results will provide new insights into gene expression with applications in biology and biomedicine.
StatusFinished
Effective start/end date3/01/1331/12/16

Funding

  • Australian Research Council (ARC): AUD360,000.00
  • Monash University