The reform of healthcare systems presents one of the most pressing and fundamental challenges for nations such as Australia. To date, hospital redesign and innovation initiatives have had limited impacts and outcomes at a system level with improvements limited to discrete areas. The aim of this inter-disciplinary research is to promote the scaling up of such initiatives to have systems-wide outcomes. The research will address institutional constraints and organisational factors and will develop practical frameworks, processes and resources. These will enable hospitals to develop organisational and leadership capacities to ensure investments in redesign and innovation have 'whole system' economic and healthcare benefits.