Electron microscopy and single-particle analysis (SPEM) is an essential tool for studying the structure and dynamics of nanoscale molecules. However, the theoretical frameworks underpinning SPEM are in their early stages of development. I here propose to develop new theory for real-time image processing of SPEM images and to design generally applicable methods for studying structural dynamics both in biology and in materials science. These developments will enable the study of colloidal nanoparticle structures in solution and reveal the protein rearrangements that underlie secretion of bacterial proteins in two different systems that are required for viability and infection by a number of different bacterial species.
|Effective start/end date||1/01/17 → 31/12/19|
- Australian Research Council (ARC): AUD293,124.00
- Australian Research Council (ARC): AUD61,100.00