To investigate how the aggregation of proteins during neuronal injury promotes neurotoxic plasmin formation

Project: Research

Status	Finished
Effective start/end date	1/01/10 → 31/12/12

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells
Samson, A. L., Ho, B., Au, A. E., Schoenwaelder, S. M., Smyth, M. J., Bottomley, S. P., Kleifeld, O. & Medcalf, R. L., 2016, In: Biology Open. 6, 11, 12 p., 160098.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
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10 Citations (Scopus)
Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase
Samson, A. L., Knaupp, A. S., Kass, I., Kleifeld, O., Marijanovic, E. M., Hughes, V. A., Lupton, C. J., Buckle, A. M., Bottomley, S. P. & Medcalf, R. L., 2014, In: Journal of Biological Chemistry. 289, 39, p. 26922 - 26936 15 p.
Research output: Contribution to journal › Article › Research › peer-review

39 Citations (Scopus)
Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait
Cops, E., Sashindranath, M., Daglas, M., Short, K. M., Pereira, C. D. F., Pang, T., Lijnen, R., Smyth, I. M., Hannan, A. J., Samson, A. L. & Medcalf, R. L., 2013, In: Experimental Neurology. 249C, p. 8 - 19 12 p.
Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Project Details