Therapeutic targeting of CIMP+ Colorectal Cancers

This grant explores the hypothesis that methylation-directed inactivation of TSGs often implicated during early onset of disease exacerbates CRC progression, and that co-targeting dysregulated epigenetic regulators in CIMP-positive tumors will restore the critical function of TSGs and potentially lead to the development of chemoprevention. Furthermore, the methylation profiling offers an opportunity to improved stratification of CRC patients.