Therapeutic targeting of CIMP+ Colorectal Cancers

  • Mahara, Sylvia, (Primary Chief Investigator (PCI))

Project: Research

Project Description

This grant explores the hypothesis that methylation-directed inactivation of TSGs often implicated during early onset of disease exacerbates CRC progression, and that co-targeting dysregulated epigenetic regulators in CIMP-positive tumors will restore the critical function of TSGs and potentially lead to the development of chemoprevention. Furthermore, the methylation profiling offers an opportunity to improved stratification of CRC patients.
Short titleDrug for colorectal cancer
StatusFinished
Effective start/end date15/08/1714/08/19

Funding

  • United States Department of Defense (DoD): AUD315,413.00