Project Details
Project Description
This grant explores the hypothesis that methylation-directed inactivation of TSGs often implicated during early onset of disease exacerbates CRC progression, and that co-targeting dysregulated epigenetic regulators in CIMP-positive tumors will restore the critical function of TSGs and potentially lead to the development of chemoprevention. Furthermore, the methylation profiling offers an opportunity to improved stratification of CRC patients.
Short title | Drug for colorectal cancer |
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Status | Finished |
Effective start/end date | 15/08/17 → 14/08/19 |
Funding
- United States Department of Defense (DOD): A$315,413.00
Equipment
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Animal Research Platform (MARP)
Christine Findlay (Manager)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility
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FlowCore
Andrew Fryga (Manager)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility
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MHTP Medical Genomics Facility
Trevor Wilson (Manager)
Hudson Institute - Department of Molecular and Translational ScienceFacility/equipment: Facility