The protective effect of maternal immunisation on stillbirth and preterm birth: does timing or number of vaccinations given together matter?

Two of the most two important unresolved challenges in modern pregnancy care are reducing preterm birth (PTB) and stillbirth. An approach that we hope will transform future outcomes, we have observed that maternal immunisation for whooping cough and influenza is associated with provide reductions in both PTB and stillbirth. PTB is reduced by 33% and stillbirth by 76% in women who are vaccinated during pregnancy. We see to understand whether the gestation when the vaccine is given or the number of vaccines given together (whooping cough and influenza versus one alone) makes a difference to the protective effect on PTB or stillbirth.