The molecular basis for efficacy at G protein coupled receptors (GPCRs)

This Project aims to investigate the molecular steps underlying the relationship between sensing by G proteincoupled receptors and cellular response. It aims to build on our ground-breaking studies that have sought to understand the primary, molecular basis for this cellular volume control. This project seeks to utilise these novel approaches to fill this knowledge gap, providing a deeper understanding of how physiology and medicines work. The anticipated outcome includes stronger national and international collaborations and enhanced capacity for understanding the fundamental biology of this receptor class. This should provide significant benefits including expanded basic knowledge and downstream improvements in drug development.