The mechanism and function of 3'UTR switching in eukaryotic cells

RNA systems interface the executive functions of DNA and the worker functions of proteins. The dynamic featuresof mRNA often dictate the level, timing and location of protein synthesis. The research program here probesglobal RNA-dynamics by custom RNA-seq and bespoke bioinformatics. Mixing classic yeast-genetics with cuttingedge RNA-technologies, the team is focused on the role of 3-UTR dynamics in eukaryotic cell biology. The projectaims to uncover conserved features, fundamental to the mechanism and function, of post-transcriptional gene-expression control. This project will bring new function to more than 30 genes involved in RNA metabolism, and abetter understanding of the causes and consequences of controlled RNA-metabolism.