The immunology of T cells in the contexts of immunity and autoimmunity

Project: Research

Project Description

T cells are key to producing successful immune responses against invading pathogens. Helper T cells detect and respond to specific antigens, producing cytokines and other signals that help B cells mount an antibody response. We are characterising the nature of these help signals in the contexts of normal immune responses and in autoimmune diseases so that we can design better vaccines and new therapies against autoimmunity. We use a range of cutting edge in vitro techniques, animal models of immunisation and autoimmune disease, and access to our world-leading biobank of human samples to study mechanisms of T and B cell immunology that will enable us to better understand the processes involved in autoimmunity. All of our research is motivated by the critical need for better therapies for autoimmune diseases, and we are closely aligned with the Rheumatology Clinical Research Group here at the Monash Medical Centre to position us best to design and test new therapeutic interventions for treatment of autoimmune diseases. These advantages have been recognised by the award of major national and international funding for us to continue our work.
StatusActive
Effective start/end date1/08/15 → …

Keywords

  • T cells
  • CD4 T cells
  • Helper T cells
  • Tfh cells
  • germinal centre
  • B cells
  • Autoimmunity
  • Lupus
  • SLE