The dynamics of viral latency in chronic infection

  • Mak, Johnson (Primary Chief Investigator (PCI))
  • Davenport, Miles (Chief Investigator (CI))
  • Kent, Stephen (Chief Investigator (CI))

Project: Research

Project Details

Project Description

Many chronic infections such as HIV persist for long periods because of the presence of latently infected cells, which lie dormant form prolonged periods and cannot be eradicated by drugs or vaccination. We have developed a unique approach to studying latency, where we can track the presence of different viral strains over time. Using an interdisciplinary team of mathematician, immunologists and virologists we will study the in vitro and in vivo dynamics of infection, latent cell production and death during Simian Immunodeficiency Virus (SIV) / Human Immunodeficiency Virus (HIV) infection. This will provide novel insights into the dynamics of latency, and aid in the rational design of anti-viral and immuno-therapies for chronic infection.
StatusFinished
Effective start/end date2/01/0931/12/11

Funding

  • Australian Research Council (ARC): AUD102,000.00