The search for critical regulators of reproduction has remained the Holy Grail for endocrinologists for over 30 years. The answer may be at hand and we are at the centre of this research. This proposal aims to explore the relationship between 3 key brain peptide hormones (kisspeptin, neurokinin B and dynorphin) in the central control of reproduction. Remarkably all 3 are produced from the same cells in the brain. The project will examine the structural and functional relationship of these cells and details the role each plays in controlling hormones from the brain that govern puberty and reproduction. Results will have far reaching implications for the treatment of infertility and enhancing reproduction in seasonally breeding species.