The Ageing Primate Brain: Molecular, Cellular and Systems-Level Insights

This project is focused on understanding the process of natural (not disease-associated) ageing of the nervous system. We know that even healthy brains change with age but still lack comprehensive knowledge of what exactly these changes are, particularly at the level of single cells and the neural circuits they form. The project will capitalize on new technologies developed in our laboratories to create the first comprehensive map of the ageing primate brain, at resolution sufficient to allow detection of changes associated with specific cell types and functional areas. The combined structural and functional data will provide unique insight on the process of ageing of the nervous system.