Research output per year
Research output per year
Project Details
Project Description
This project aims to identify small molecules (fragments) that bind to the oxidoreductase enzyme DsbA from Pseudomonas Aeruginosa (PaDsbA). These fragments will be elaborated to generate compounds that bind with higher affinity and inhibit the activity of PaDsbA. Such inhibitors would provide a starting point for the development of antibacterial agents with a novel mode of action, which are urgently required for treatment of multidrug resistant infections.
| Status | Finished |
|---|---|
| Effective start/end date | 31/03/10 → 31/12/12 |
Funding
- Australian Research Council (ARC): A$600,000.00
- Biota Holdings Ltd: A$180,000.00
Research output
- 2 Article
-
Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1
Mohanty, B., Rimmer, K., McMahon, R. M., Headey, S. J., Vazirani, M., Shouldice, S. R., Coinçon, M., Tay, S., Morton, C. J., Simpson, J. S., Martin, J. L. & Scanlon, M. J., 1 Mar 2017, In: PLoS ONE. 12, 3, 20 p., e0173436.Research output: Contribution to journal › Article › Research › peer-review
File14 Citations (Scopus) -
Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility
McMahon, R. M., Coincon, M., Tay, S., Heras, B., Morton, C. J., Scanlon, M. J. & Martin, J. L., 2015, In: Acta Crystallographica Section D: Biological Crystallography. 71, 12, p. 2386-2395 10 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus)
Equipment
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Australian Synchrotron
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility