Targeting virulence of Pseudomonas aeruginosa by inhibiting oxidative protein folding

This project aims to identify small molecules (fragments) that bind to the oxidoreductase enzyme DsbA from Pseudomonas Aeruginosa (PaDsbA). These fragments will be elaborated to generate compounds that bind with higher affinity and inhibit the activity of PaDsbA. Such inhibitors would provide a starting point for the development of antibacterial agents with a novel mode of action, which are urgently required for treatment of multidrug resistant infections.