Targeting the Plasmodium falciparum Metalloaminopeptidases for Development of New Antimalarial Agents

Research output

Research output per year 2014 2014 2015 2017 2019 2019

• 11 Article
• 1 Review Article

Research output per year

Research output per year

Search results

• 2019

  Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases

  Vinh, N. B., Drinkwater, N., Malcolm, T. R., Kassiou, M., Lucantoni, L., Grin, P. M., Butler, G. S., Duffy, S., Overall, C. M., Avery, V. M., Scammells, P. J. & McGowan, S., 24 Jan 2019, In: Journal of Medicinal Chemistry. 62, 2, p. 622-640 19 p.

  Research output: Contribution to journal › Article › Research › peer-review
  26 Citations (Scopus)

• Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions

  Lee, J., Vinh, N. B., Drinkwater, N., Yang, W., Kannan Sivaraman, K., Schembri, L. S., Gazdik, M., Grin, P. M., Butler, G. S., Overall, C. M., Charman, S. A., McGowan, S. & Scammells, P. J., 8 Aug 2019, In: Journal of Medicinal Chemistry. 62, 15, p. 7185-7209 25 p.

  Research output: Contribution to journal › Article › Research › peer-review
  18 Citations (Scopus)
• 2018

  Mapping the Pathway and Dynamics of Bestatin Inhibition of the Plasmodium falciparum M1 Aminopeptidase PfA-M1

  Yang, W., Riley, B. T., Lei, X., Porebski, B. T., Kass, I., Buckle, A. M. & McGowan, S., 6 Dec 2018, In: ChemMedChem. 13, 23, p. 2504-2513 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  10 Citations (Scopus)
• 2017

  Generation of AMBER force field parameters for zinc centres of M1 and M17 family aminopeptidases

  Yang, W., Riley, B. T., Lei, X., Porebski, B. T., Kass, I., Buckle, A. M. & McGowan, S., 28 Aug 2017, In: Journal of Biomolecular Structure and Dynamics. 36, 10, p. 2595-2604 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  13 Citations (Scopus)
• 2016

  Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum

  Drinkwater, N., Kannan Sivaraman, K., Bamert, R. S., Rut, W., Mohamed, K., Vinh, N. B., Scammells, P. J., Drag, M. & McGowan, S., 27 Sept 2016, In: Biochemical Journal. 473, 19, p. 3189-3204 16 p.

  Research output: Contribution to journal › Article › Research › peer-review
  11 Citations (Scopus)
• 2015

  Screening the medicines for malaria venture "malaria box" against the plasmodium falciparum aminopeptidases, M1, M17 and M18

  Paiardini, A., Bamert, R. S., Kannan Sivaraman, K., Drinkwater, N., Mistry, S. N., Scammells, P. J. & McGowan, S., 2015, In: PLoS ONE. 10, 2, 14 p., e0115859.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  36 Citations (Scopus)

• X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17

  Drinkwater, N., Bamert, R. S., Kannan Sivaraman, K., Paiardini, A. & McGowan, S., 2015, In: Proteins: Structure, Function and Bioinformatics. 83, 4, p. 789 - 795 7 p.

  Research output: Contribution to journal › Article › Research › peer-review
  12 Citations (Scopus)
• 2014

  Aminopeptidase N1 (EtAPN1), an M1 metalloprotease of the apicomplexan parasite Eimeria tenella, participates in parasite development

  Gras, S., Byzia, A., Gilbert, F. B., McGowan, S., Drag, M., Silvestre, A., Niepceron, A., Lecaille, F., Lalmanach, G. & Brossier, F., 2014, In: Eukaryotic Cell. 13, 7, p. 884 - 895 12 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  19 Citations (Scopus)

• From crystal to compound: structure-based antimalarial drug discovery

  Drinkwater, N. & McGowan, S., 2014, In: Biochemical Journal. 461, 3, p. 349 - 369 21 p.

  Research output: Contribution to journal › Article › Research › peer-review
  21 Citations (Scopus)

• Operation of the Australian Store.Synchrotron for macromolecular crystallography

  Meyer, G. R., Aragao, D., Mudie, N. J., Caradoc-Davies, T. T., McGowan, S., Bertling, P. J., Groenewegen, D., Quenette, S. M., Bond, C. S., Buckle, A. M. & Androulakis, S. G., 2014, In: Acta Crystallographica Section D: Biological Crystallography. 70, 10, p. 2510 - 2519 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  23 Citations (Scopus)

• Understanding the structural dynamics of TCR-pMHC complex interactions

  Kass, I., Buckle, A. M. & Borg, N. A., 2014, In: Trends in Immunology. 35, 12, p. 604 - 612 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  41 Citations (Scopus)