Targeting necroptosis in the race to treat acute and chronic inflammation

  • Hildebrand, Joanne M (Primary Chief Investigator (PCI))
  • Speir, Mary (Chief Investigator (CI))
  • Lawlor, Kate (Associate Investigator (AI))
  • Jackson, Victoria (Associate Investigator (AI))
  • Pearson, Jaclyn (Associate Investigator (AI))
  • Hachani, Abderrahman (Associate Investigator (AI))
  • Ascher, David B (Associate Investigator (AI))
  • Murphy, James (Associate Investigator (AI))
  • Slade, Charlotte A. (Associate Investigator (AI))

Project: Research

Project Details

Project Description

Necroptosis, a form of programmed cell death, is an important weapon used by our bodies to prevent the spread of viruses, bacteria and even cancer. We have discovered that many populations have developed genetic changes that may enhance necroptosis and increase inflammation in the body. We propose that these changes are the key to understanding why only some people develop severe life threatening symptoms to infections, and the key to designing more effective therapies for inflammatory diseases.
Short titleNecroptosis and inflammation
StatusActive
Effective start/end date1/01/22 → 31/12/25

Keywords

  • cell death
  • animal models
  • inflamatory diseases
  • sepsis
  • pro-inflammatory alleles