Targeting MD hetero-resistant Gram-negatives: PK/PD for rational combinations.

Research output

Research output per year 2009 2010 2011 2012 2015

• 39 Article
• 1 Chapter (Book)

Research output per year

Research output per year

Search results

• 2015

  Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance

  Ly, N. S., Bulitta, J. B., Rao, G. G., Landersdorfer, C. B., Holden, P. N., Forrest, A., Bergen, P. J., Nation, R. L., Li, J. & Tsuji, B., 2015, In: Journal of Antimicrobial Chemotherapy. 70, 5, p. 1434 - 1442 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  58 Citations (Scopus)

• Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK

  Pennington, M. W., Chang, S. J., Chauhan, S., Huq, R., Tajhya, R. B., Chhabra, S., Norton, R. S. & Beeton, C., 2015, In: Marine Drugs. 13, 1, p. 529 - 542 14 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  57 Citations (Scopus)

• Novel rate-area-shape modeling approach to quantify bacterial killing and regrowth for in vitro static time-kill studies

  Cheah, S-E., Li, J., Nation, R. L. & Bulitta, J. B., 2015, In: Antimicrobial Agents and Chemotherapy. 59, 1, p. 381 - 388 8 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  11 Citations (Scopus)

• Polymyxin combinations: pharmacokinetics and pharmacodynamics for rationale use

  Bergen, P. J., Bulman, Z. P., Saju, S. M., Bulitta, J. B., Landersdorfer, C. B., Forrest, A., Li, J., Nation, R. L. & Tsuji, B., 2015, In: Pharmacotherapy. 35, 1, p. 34 - 42 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  49 Citations (Scopus)

• The transcriptomic response of Acinetobacter baumannii to colistin and doripenem alone and in combination in an in vitro pharmacokinetics/pharmacodynamics model

  Henry, R. M., Crane, B. A., Powell, D. R., Deveson-Lucas, D. S., Li, Z., Aranda, J., Harrison, P. F., Nation, R. L., Adler, B., Harper, M., Boyce, J. D. & Li, J., 2015, In: Journal of Antimicrobial Chemotherapy. 70, 5, p. 1303 - 1313 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  71 Citations (Scopus)
• 2014

  Development and validation of a liquid chromatography-mass spectrometry assay for polymyxin B in bacterial growth media

  Cheah, S-E., Bulitta, J. B., Li, J. & Nation, R. L., 2014, In: Journal of Pharmaceutical and Biomedical Analysis. 92, p. 177 - 182 6 p.

  Research output: Contribution to journal › Article › Research › peer-review
  39 Citations (Scopus)

• New dosing strategies for an old antibiotic: Pharmacodynamics of front-loaded regimens of colistin at simulated pharmacokinetics in patients with kidney or liver disease

  Rao, G. G., Ly, N. S., Haas, C. E., Garonzik, S. M., Forrest, A., Bulitta, J. B., Kelchlin, P. A., Holden, P. N., Nation, R. L., Li, J. & Tsuji, B., 2014, In: Antimicrobial Agents and Chemotherapy. 58, 3, p. 1381 - 1388 8 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  32 Citations (Scopus)

• Pharmacokinetics and pharmacodynamics of colistin

  Nation, R. L., Bergen, P. J. & Li, J., 2014, Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics. Vinks, A. A., Derendorf, H. & Mouton, J. W. (eds.). New York NY USA: Springer, p. 351 - 380 30 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review
  2 Citations (Scopus)

• Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae

  Velkov, T., Deris, Z. Z., Huang, J. X., Azad, M. A. K., Butler, M., Sivanesan, S., Kaminskas, L. M., Dong, Y. D. C., Boyd, B. J., Baker, M. A., Cooper, M. A., Nation, R. L. & Li, J., 2014, In: Innate Immunity. 20, 4, p. 350 - 363 14 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  55 Citations (Scopus)
• 2013

  In vitro toxicity of colistin on primary chick cortex neurons and its potential mechanism

  Dai, C., Zhang, D., Gao, R., Zhang, X., Li, J. & Li, J., 2013, In: Environmental Toxicology and Pharmacology. 36, 2, p. 659 - 666 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  17 Citations (Scopus)

• Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A

  Velkov, T., Soon, R. L-X., Huang, J. X., Cooper, M. A., Azad, M. A. K., Baker, M. A., Thompson, P., Roberts, K. D., Nation, R. L., Clements, A., Strugnell, R. A. & Li, J., 2013, In: Innate Immunity. 19, 3, p. 265 - 277 13 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  35 Citations (Scopus)

• Pharmacology of polymyxins: New insights into an 'old' class of antibiotics

  Velkov, T., Roberts, K. D., Nation, R. L., Thompson, P. & Li, J., 2013, In: Future Microbiology. 8, 6, p. 711 - 724 14 p.

  Research output: Contribution to journal › Article › Research › peer-review
  373 Citations (Scopus)

• Species-dependent blood-brain barrier disruption of lipopolysaccharide: Amelioration by colistin in vitro and in vivo

  Jin, L., Nation, R. L., Li, J. & Nicolazzo, J., 2013, In: Antimicrobial Agents and Chemotherapy. 57, 9, p. 4336 - 4342 7 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  30 Citations (Scopus)

• Synergistic activity of colistin and rifampin combination against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacokinetic/ pharmacodynamic model

  Lee, H. J., Bergen, P. J., Bulitta, J. B., Tsuji, B., Forrest, A., Nation, R. L. & Li, J., 2013, In: Antimicrobial Agents and Chemotherapy. 57, 8, p. 3738 - 3745 8 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  94 Citations (Scopus)
• 2012

  Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics

  Yousef, J. M., Chen, G., Hill, P. A., Nation, R. L. & Li, J., 2012, In: Journal of Antimicrobial Chemotherapy. 67, 2, p. 452 - 459 8 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  125 Citations (Scopus)

• Cell surface hydrophobicity of colistin-susceptible vs resistant Acinetobacter baumannii determined by contact angles: methodological considerations and implications

  Soon, R. L-X., Li, J., Boyce, J. D., Harper, M., Adler, B., Larson, I. C. & Nation, R. L., 2012, In: Journal of Applied Microbiology. 113, 4, p. 940 - 951 12 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  9 Citations (Scopus)

• Drug-binding energetics of human a-1-acid glycoprotein assessed by isothermal titration calorimetry and molecular docking simulations

  Huang, J. X., Cooper, M. A., Baker, M. A., Azad, M. A. K., Nation, R. L., Li, J. & Velkov, T., 2012, In: Journal of Molecular Recognition. 25, 12, p. 642 - 656 15 p.

  Research output: Contribution to journal › Article › Research › peer-review
  22 Citations (Scopus)

• Drug release from nanomedicines: Selection of appropriate encapsulation and release methodology

  Wallace, S. J., Li, J., Nation, R. L. & Boyd, B. J., 2012, In: Drug Delivery and Translational Research. 2, p. 284 - 292 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  170 Citations (Scopus)

• Effect of systemic infection induced by pseudomonas aeruginosa on the brain uptake of colistin in mice

  Jin, L., Li, J., Nation, R. L. & Nicolazzo, J., 2012, In: Antimicrobial Agents and Chemotherapy. 56, 10, p. 5240 - 5246 7 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  17 Citations (Scopus)

• Interaction of colistin and colistin methanesulfonate with liposomes: colloidal aspects and implications for formulation

  Wallace, S. J., Li, J., Nation, R. L., Prankerd, R. J. & Boyd, B. J., 2012, In: Journal of Pharmaceutical Sciences. 101, 9, p. 3347 - 3359 13 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  32 Citations (Scopus)

• Molecular characterization of lipopolysaccharide binding to human alpha-1-acid glycoprotein

  Huang, J. X., Azad, M. A. K., Yuriev, E., Baker, M. A., Nation, R. L., Li, J., Cooper, M. A. & Velkov, T., 2012, In: Journal of Lipids. 2012, p. 1 - 15 15 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

• 'Old' antibiotics for emerging multidrug-resistant bacteria

  Bergen, P. J., Landersdorfer, C. B., Lee, H. J., Li, J. & Nation, R. L., 2012, In: Current Opinion in Infectious Diseases. 25, 6, p. 626 - 633 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  113 Citations (Scopus)

• Pharmacokinetics and pharmacodynamics of 'old' polymyxins: What is new?

  Bergen, P. J., Landersdorfer, C. B., Zhang, J., Zhao, M., Lee, H. J., Nation, R. L. & Li, J., 2012, In: Diagnostic Microbiology and Infectious Disease. 74, 3, p. 213 - 223 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  139 Citations (Scopus)

• Structure-activity relationships for the binding of polymyxins with human alpha-1-acid glycoprotein

  Azad, M. A. K., Huang, J. X., Cooper, M. A., Roberts, K. D., Thompson, P., Nation, R. L., Li, J. & Velkov, T., 2012, In: Biochemical Pharmacology. 84, 3, p. 278 - 291 14 p.

  Research output: Contribution to journal › Article › Research › peer-review
  42 Citations (Scopus)

• The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model

  Deris, Z. Z., Yu, H., Davis, K. E., Soon, R. L-X., Jacob, J., Ku, K. U. C., Poudyal, A., Bergen, P. J., Tsuji, B., Bulitta, J. B., Forrest, A., Paterson, D. L., Velkov, T., Li, J. & Nation, R. L., 2012, In: Antimicrobial Agents and Chemotherapy. 56, 10, p. 5103 - 5112 10 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  85 Citations (Scopus)
• 2011

  Clinically relevant plasma concentrations of colistin in combination with imipenem enhance pharmacodynamic activity against multidrug-resistant peudomonas aeruginosa at multiple inocula

  Bergen, P., Forrest, A., Bulitta, J., Tsuji, B., Sidjabat, H., Paterson, D., Li, J. & Nation, R., 2011, In: Antimicrobial Agents and Chemotherapy. 55, 11, p. 5134 - 5142 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  105 Citations (Scopus)

• Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions

  Soon, R., Velkov, T., Chiu, F., Thompson, P., Kancharla, R., Roberts, K., Larson, I., Nation, R. & Li, J., 2011, In: Analytical Biochemistry. 409, 2, p. 273 - 283 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  42 Citations (Scopus)

• Different surface charge of colistin-susceptible and -resistant acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment

  Soon, R., Nation, R., Cockram, S., Moffatt, J., Harper, M., Adler, B., Boyce, J., Larson, I. & Li, J., 2011, In: Journal of Antimicrobial Chemotherapy. 66, 1, p. 126 - 133 8 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  101 Citations (Scopus)

• Dosing of colistin - back to basic PK/PD

  Bergen, P., Li, J. & Nation, R., 2011, In: Current Opinion in Pharmacology. 11, 5, p. 464 - 469 6 p.

  Research output: Contribution to journal › Article › Research › peer-review
  78 Citations (Scopus)

• Effect of colistin exposure and growth phase on the surface properties of live Acinetobacter baumannii cells examined by atomic force microscopy

  Soon, R., Nation, R., Harper, M., Adler, B., Boyce, J., Tan, C-H., Li, J. & Larson, I., 2011, In: International Journal of Antimicrobial Agents. 38, 6, p. 493 - 501 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  31 Citations (Scopus)

• Melatonin attenuates colistin-induced nephrotoxicity in rats

  Yousef, J., Chen, G., Hill, P., Nation, R. & Li, J., 2011, In: Antimicrobial Agents and Chemotherapy. 55, 9, p. 4044 - 4049 6 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  109 Citations (Scopus)

• Synergistic killing of multidrug-resistant Pseudomonas aeruginosa at multiple inocula by colistin combined with doripenem in an in vitro pharmacokinetic/pharmacodynamic model

  Bergen, P., Tsuji, B., Bulitta, J., Forrest, A., Jacob, J., Sidjabat, H., Paterson, D., Nation, R. & Li, J., 2011, In: Antimicrobial Agents and Chemotherapy. 55, 12, p. 5685 - 5695 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  102 Citations (Scopus)
• 2010

  Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models

  Dudhani, R., Turnidge, J. D., Coulthard, K., Milne, R., Rayner, C. R., Li, J. & Nation, R. L., 2010, In: Antimicrobial Agents and Chemotherapy. 54, 3, p. 1117 - 1124 8 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  165 Citations (Scopus)

• Evaluating the stability of colistin and colistin methanesulphonate in human plasma under different conditions of storage

  Dudhani, R., Nation, R. L. & Li, J., 2010, In: Journal of Antimicrobial Chemotherapy. 65, p. 1412 - 1415 4 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  46 Citations (Scopus)

• fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models

  Dudhani, R., Turnidge, J., Nation, R. & Li, J., 2010, In: Journal of Antimicrobial Chemotherapy. 65, 9, p. 1984 - 1990 7 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  156 Citations (Scopus)

• Pharmacokinetic/pharmacodynamic investigation of colistin against Pseudomonas aeruginosa using an in vitro model

  Bergen, P. J., Bulitta, J. B., Forrest, A., Tsuji, B., Li, J. & Nation, R. L., 2010, In: Antimicrobial Agents and Chemotherapy. 54, 9, p. 3783 - 3789 7 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  144 Citations (Scopus)

• Self-assembly behavior of colistin and its prodrug colistin methanesulfonate: implications for solution stability and solubilization

  Wallace, S. J., Li, J., Nation, R. L., Prankerd, R. J., Velkov, T. & Boyd, B. J., 2010, In: Journal of Physical Chemistry B. 114, p. 4836 - 4840 5 p.

  Research output: Contribution to journal › Article › Research › peer-review
  62 Citations (Scopus)

• Structure-Activity Relationships of Polymyxin Antibiotics

  Velkov, T., Thompson, P., Nation, R. L. & Li, J., 2010, In: Journal of Medicinal Chemistry. 53, p. 1898 - 1916 19 p.

  Research output: Contribution to journal › Article › Research › peer-review
  605 Citations (Scopus)
• 2009

  Atomic force microscopy investigation of the morphology and topography of colistin-heteroresistant Acinetobacter baumannii strains as a function of growth phase and in response to colistin treatment

  Soon, R. L-X., Nation, R. L., Hartley, P., Larson, I. C. & Li, J., 2009, In: Antimicrobial Agents and Chemotherapy. 53, 12, p. 4979 - 4986 8 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  55 Citations (Scopus)

• Colistin in the 21st century

  Nation, R. L. & Li, J., 2009, In: Current Opinion in Infectious Diseases. 22, 6, p. 535 - 543 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  371 Citations (Scopus)