Targeting diet-microbiome interactions in Huntington's Disease

  • Glikmann-Johnston, Yifat (Primary Chief Investigator (PCI))
  • Stout, Julie (Chief Investigator (CI))
  • Hannan, Anthony (Chief Investigator (CI))
  • Choo, Jocelyn M. (Chief Investigator (CI))
  • Rogers, Geraint B. (Chief Investigator (CI))
  • Wasser, Cory (Chief Investigator (CI))

Project: Research

Project Details

Project Description

Unintended weight loss is hallmark clinical feature of Huntington’s disease (HD), an inherited and fatal neurodegenerative disorder. The cause of weight loss in HD is unknown, but people with HD who have high body mass index have a slower rate of deterioration in motor function and cognition. Regulation of body weight is mediated by the gut microbiome via metabolic pathways. Our group showed the first evidence of changes in microbiota composition (or gut dysbiosis) in stool samples from people with HD. Given that diet is a main modifier of the microbial environment, foundational studies on diet-microbiome associations in HD are essential to examine the potential to affect gut alignments in HD. This project will compare the dietary intake and gut microbiome of HD gene expansion carriers and healthy controls, and determine the relationship between dietary intake and bacterial diversity and taxonomic composition of the HD gut microbiome.
Turner Strategic Project Grant, 2021, $40,000
StatusActive
Effective start/end date17/03/2131/12/21

Keywords

  • Huntington's Disease
  • Gut microbiome
  • Diet
  • cognition