Targeting an impending global disaster: the mismatch between increasingly drug-resistant superbugs and development of new antibiotics

  • Li, Jian (Primary Chief Investigator (PCI))

Project: Research

Project Description

Antibiotic resistance is one of the 3 greatest threats to human health globally. No new antibiotic against
Gram-negative superbugs is expected to be available in the next decade. Polymyxin is the last-line antibiotic
for such infections, but with little pharmacological information available. This proposal will employ a
multidisciplinary approach to develop novel lipopeptides as new antibiotics against Gram-negative
superbugs, in particular those resistant to polymyxin. Investigations on mechanisms of polymyxin resistance
and activity, and pharmacology of polymyxin will provide vital information for designing superior and safer
lipopeptides. This proposal targets the impending global disaster (i.e. Bad Bugs, No Drugs) in a timely
manner.
StatusFinished
Effective start/end date17/11/1016/11/14

Funding

  • Australian Research Council (ARC): AUD506,552.00
  • Australian Research Council (ARC): AUD160,942.00
  • Australian Research Council (ARC)
  • Australian Research Council (ARC)