Systems approaches to understanding mitochondrial function and dysfunction in disease

Stroud, David (Primary Chief Investigator (PCI))

Biochemistry & Molecular Biology

Project: Research

Status	Finished
Effective start/end date	1/01/18 → 31/12/21

Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2
Wu, Y., Lim, Y.-W., Stroud, D. A., Martel, N., Hall, T. E., Lo, H. P., Ferguson, C., Ryan, M. T., McMahon, K.-A. & Parton, R. G., 13 Mar 2023, In: Developmental Cell. 58, 5, p. 376-397.e1-4 27 p.
Research output: Contribution to journal › Article › Research › peer-review

27 Link opens in a new tab Citations (Scopus)
Multi-omics identifies large mitoribosomal subunit instability caused by pathogenic MRPL39 variants as a cause of pediatric onset mitochondrial disease
Amarasekera, S. S. C., Hock, D. H., Lake, N. J., Calvo, S. E., Grønborg, S. W., Krzesinski, E. I., Amor, D. J., Fahey, M. C., Simons, C., Wibrand, F., Mootha, V. K., Lek, M., Lunke, S., Stark, Z., Østergaard, E., Christodoulou, J., Thorburn, D. R., Stroud, D. A. & Compton, A. G., 20 Jul 2023, In: Human Molecular Genetics. 32, 15, p. 2441-2454 14 p.
Research output: Contribution to journal › Article › Research › peer-review

21 Link opens in a new tab Citations (Scopus)
AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5
Salscheider, S. L., Gerlich, S., Cabrera-Orefice, A., Peker, E., Rothemann, R. A., Murschall, L. M., Finger, Y., Szczepanowska, K., Ahmadi, Z. A., Guerrero-Castillo, S., Erdogan, A., Becker, M., Ali, M., Habich, M., Petrungaro, C., Burdina, N., Schwarz, G., Klußmann, M., Neundorf, I. & Stroud, D. A. & 4 others, Ryan, M. T., Trifunovic, A., Brandt, U. & Riemer, J., 1 Sept 2022, In: The EMBO Journal. 41, 17, 21 p., e110784.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

39 Link opens in a new tab Citations (Scopus)

FlowCore (FLOW)
Fryga, A. (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
Monash Micro Imaging (MMI)
Firth, S. (Manager), Fulcher, A. (Operator), Chernyavskiy, O. (Operator), Rzeszutek, M. (Other), Potter, D. (Manager), Hilsenstein, V. (Operator), Nunez-Iglesias, J. (Other), Cody, S. (Manager), Carmichael, I. (Operator), Kouskousis, B. (Other), Creed, S. (Manager) & Ballerin, G. (Operator)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
Monash Proteomics & Metabolomics Platform (MPMP)
Schittenhelm, R. (Other) & Steer, D. (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility

Systems approaches to understanding mitochondrial function and dysfunction in disease

Project Details

Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2

Multi-omics identifies large mitoribosomal subunit instability caused by pathogenic MRPL39 variants as a cause of pediatric onset mitochondrial disease

AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5

FlowCore (FLOW)

Monash Micro Imaging (MMI)

Monash Proteomics & Metabolomics Platform (MPMP)

Systems approaches to understanding mitochondrial function and dysfunction in disease

Project Details

Research output

Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2

Multi-omics identifies large mitoribosomal subunit instability caused by pathogenic MRPL39 variants as a cause of pediatric onset mitochondrial disease

AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5

Equipment

FlowCore (FLOW)

Monash Micro Imaging (MMI)

Monash Proteomics & Metabolomics Platform (MPMP)