Structural studies of mammalian dimeric dihydrodiol dehydrogenase and L-xylulose reductase.

  • El-Kabbani, Ossama (Primary Chief Investigator (PCI))
  • Hara, Akira (Chief Investigator (CI))

Project: Research

Project Details

Project Description

The aim of this research is determine the structures and mechanisms of mammalian dimeric dihrodiol dehydrogenase and L-xylulose reductase. Mammalian dihydrodiol dehydrogenase exists in multiple forms in mammalian tissues. The dimeric form of the enzyme has a primary structure distinct from previously known mammalian enzymes and may constitute a novel protein family with prokaryotic proteins. L-Xylulose reductase is an enzyme of the uronate cycle that accounts for about 5% of the total glucose metabolism per day in humans. We propose to determine the first structure of a L-xylulose reductase.
StatusFinished
Effective start/end date14/04/0331/12/06

Funding

  • Australian Research Council (ARC): AUD54,000.00