Structural characterisation of the co-inhibitory complex formed by the tumour suppressor PTEN and the metastatic factor PREX2

Ellisdon, Andrew (Primary Chief Investigator (PCI))
Elmlund, Hans (Chief Investigator (CI))
Halls, Michelle (Chief Investigator (CI))

Project: Research

Short title	Structure of the co-inhibitory PTEN:PREX2 complex
Status	Finished
Effective start/end date	1/01/18 → 31/12/20

2 Article

Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism
Chang, Y. G., Lupton, C. J., Bayly-Jones, C., Keen, A. C., D’Andrea, L., Lucato, C. M., Steele, J. R., Venugopal, H., Schittenhelm, R. B., Whisstock, J. C., Halls, M. L. & Ellisdon, A. M., Aug 2022, In: Nature Structural & Molecular Biology. 29, 8, p. 767–773 25 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

5 Citations (Scopus)
Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1
D’Andrea, L., Lucato, C. M., Marquez, E. A., Chang, Y-G., Civciristov, S., Mastos, C., Lupton, C. J., Huang, C., Elmlund, H., Schittenhelm, R. B., Mitchell, C. A., Whisstock, J. C., Halls, M. L. & Ellisdon, A. M., 4 May 2021, In: Science Signaling. 14, 681, 16 p., eabc4078.
Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Macromolecular Crystallisation Facility
Geoffrey Kong (Operator)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
MASSIVE
Slava Kitaeff (Manager) & David Powell (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)
Facility/equipment: Facility
Micromon
Scott Coutts (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility