Structural and functional characterisation of the oncogene P-Rex1

Project: Research

Status	Finished
Effective start/end date	1/01/17 → 31/12/19

Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism
Chang, Y. G., Lupton, C. J., Bayly-Jones, C., Keen, A. C., D’Andrea, L., Lucato, C. M., Steele, J. R., Venugopal, H., Schittenhelm, R. B., Whisstock, J. C., Halls, M. L. & Ellisdon, A. M., Aug 2022, In: Nature Structural & Molecular Biology. 29, 8, p. 767–773 25 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

6 Citations (Scopus)
Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1
D’Andrea, L., Lucato, C. M., Marquez, E. A., Chang, Y.-G., Civciristov, S., Mastos, C., Lupton, C. J., Huang, C., Elmlund, H., Schittenhelm, R. B., Mitchell, C. A., Whisstock, J. C., Halls, M. L. & Ellisdon, A. M., 4 May 2021, In: Science Signaling. 14, 681, 16 p., eabc4078.
Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)
P-Rex1 and P-Rex2 RacGEFs and cancer
Srijakotre, N., Man, J., Ooms, L. M., Lucato, C. M., Ellisdon, A. M. & Mitchell, C. A., 15 Aug 2017, In: Biochemical Society Transactions. 45, 4, p. 963-977 15 p.
Research output: Contribution to journal › Review Article › Research › peer-review

Open Access
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38 Citations (Scopus)

Project Details