Structural and functional characterisation of compounds that inhibit the malarial aminopeptidases.

Project: Research

Project Description

Malaria parasites, specifically Plasmodium falciparum (Pf), are responsible for the deaths of over 2 million people per annum. Amongst the extensive Pf proteome three genetically essential protease enzymes (PfMAPs) are involved in haemoglobin breakdown, acting in concert to provide the parasite with nutrients. This process is essential for parasitic survival and therefore an ideal target for chemotheraputic intervention strategies. This application aims to structurally characterise these essential PfMAPs to further understand how they work and how compounds might intervene to inhibit their function, thus preventing malaria.
StatusFinished
Effective start/end date1/01/115/01/15

Funding

  • Australian Research Council (ARC): AUD506,552.00
  • Australian Research Council (ARC): AUD180,000.00
  • Monash University