Structural analysis of poxviruses: advancing our understanding of complex DNA viruses and their in vivo crystals.

Project: Research

Project Description

Poxviruses are arguably the largest viruses infecting animals and humans. The sheer complexity of their virions sets them apart in the virus world and has limited our understanding of the viral assembly. This project will use innovative structural approaches to understand the formation of two key assemblies of poxviruses: the immature particles, a potential vulnerable step in viral assembly, and virus-containing crystals called spheroids, the main infectious form of insect poxviruses.
The molecular understanding of these processes will be exploited to develop a pipeline for the discovery of inhibitors of poxvirus assembly and crystalline microparticles as a novel vaccine-delivery platform.
StatusFinished
Effective start/end date31/12/121/09/17

Funding

  • Australian Research Council (ARC): AUD514,528.00
  • Australian Research Council (ARC): AUD196,000.00