Stochastic modelling of genetic regulatory networks with burst process

The central aim of this project is to develop cutting-edge modelling frameworks by incorporating burst
process in gene expression into stochastic models in order to achieve deeper insights into the mechanisms
that regulate gene expression. Using two important genetic networks as the testable paradigm, realistic
models will be designed for the first time to examine the critical functions of burst process in generating cellto-
cell variations. Computer simulations will provide reconciliation between hypotheses and may lead to
discoveries regarding the regulatory mechanisms in gene expression. The novel and rigorous approaches
are capable to model a wide range of biological systems with burst process.