Project Details
Project Description
Diabetes is the leading cause of chronic kidney disease. Over the last decade our work has shown that Angiotensin Converting Enzyme 2 (ACE2) is important for the development and progression of kidney disease in diabetes. We have discovered a new RNA therapy that is able to safely and selectively increase ACE2 in the kidney. In this project, we will test this RNA therapy in an murine model of type 2 diabetes, as the first step toward a potential new treatment for diabetic kidney disease.
| Short title | Splice-switching oligonucleotides targeting ACE2 |
|---|---|
| Status | Active |
| Effective start/end date | 1/02/23 → … |