Spatio-temporal modelling of Ras dependent MAP kinase activation

  • Tian, Tianhai (Primary Chief Investigator (PCI))
  • Hancock, John (Chief Investigator (CI))

Project: Research

Project Details

Project Description

The major aim of the project is to develop novel mathematical models that yield deep insights into cellular signal transduction pathways. This involves designing a simulation framework that uses both stochastic and deterministic processes to stimulate the spatial and temporal dynamics of complex biological systems. It will be the first time that the spatial heterogeneity of a cell is fully realized in mathematical models of signalling pathways. Hybrid models for biochemical reactions in different subcellular and membrane compartments will enable us to rationalize the interpretation of recent experimental data sets. In addition, testable predictions from realistic mathematical models will identify new directions for experimental discovery.
Effective start/end date2/01/0731/12/11


  • Australian Research Council (ARC): A$142,202.00
  • Australian Research Council (ARC): A$289,842.00