Role of programmed cell death in NLRP3 inflammasome activation and Metabolic Syndrome

Lawlor, Kathryn (Primary Chief Investigator (PCI))

Hudson Institute - Centre for Innate Immunity and Infectious Disease

Project: Research

Short title	Cell death in Type 2 Diabetes
Status	Finished
Effective start/end date	1/01/19 → 31/12/22

11 Article
3 Review Article
1 Editorial

Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in mice
Tye, H., Conos, S. A., Djajawi, T. M., Gottschalk, T. A., Abdoulkader, N., Kong, I. Y., Kammoun, H. L., Narayana, V. K., Kratina, T., Speir, M., Emery, J., Simpson, D. S., Hall, C., Vince, A. J., Russo, S., Crawley, R., Rashidi, M., Hildebrand, J. M., Murphy, J. M. & Whitehead, L. & 8 others, De Souza, D. P., Masters, S. L., Samson, A. L., Lalaoui, N., Hawkins, E. D., Murphy, A. J., Vince, J. E. & Lawlor, K. E., Jan 2025, In: Life Science Alliance. 8, 1, 24 p., e202302446.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

9 Link opens in a new tab Citations (Scopus)
NLRP3 inflammasome–driven hemophagocytic lymphohistiocytosis occurs independent of IL-1β and IL-18 and is targetable by BET inhibitors
Shojaee, F., Azadian, E., Wong, M. X., Ma, X., Rickard, J., Pang, J., Hall, C., Kueh, A. J., Masters, S. L., Rioja, I., Prinjha, R. K., Doerflinger, M., Lawlor, K. E., Rashidi, M. & Vince, J. E., 9 Jul 2025, In: Science Advances. 11, 28, 16 p., eadv0079.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

1 Link opens in a new tab Citation (Scopus)
Murine norovirus infection of macrophages induces intrinsic apoptosis as the major form of programmed cell death
Deerain, J. M., Aktepe, T. E., Trenerry, A. M., Ebert, G., Hyde, J. L., Charry, K., Edgington-Mitchell, L., Xu, B., Ambrose, R. L., Sarvestani, S. T., Lawlor, K. E., Pearson, J. S., White, P. A. & Mackenzie, J. M., Jan 2024, In: Virology. 589, 12 p., 109921.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

7 Link opens in a new tab Citations (Scopus)

Monash Animal Research Platform (MARP)
Findlay, C. (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
Monash Micro Imaging (MMI)
Firth, S. (Manager), Fulcher, A. (Operator), Chernyavskiy, O. (Operator), Rzeszutek, M. (Other), Potter, D. (Manager), Hilsenstein, V. (Operator), Nunez-Iglesias, J. (Other), Cody, S. (Manager), Carmichael, I. (Operator), Kouskousis, B. (Other), Creed, S. (Manager) & Ballerin, G. (Operator)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility

Role of programmed cell death in NLRP3 inflammasome activation and Metabolic Syndrome

Project Details

Research output

Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in mice

NLRP3 inflammasome–driven hemophagocytic lymphohistiocytosis occurs independent of IL-1β and IL-18 and is targetable by BET inhibitors

Murine norovirus infection of macrophages induces intrinsic apoptosis as the major form of programmed cell death

Equipment

Monash Animal Research Platform (MARP)

Monash Micro Imaging (MMI)