RNA-mediated regulation of the histone methyltransferase PRC2: a new link to disease-associated and causing mutations

Davidovich, Chen (Primary Chief Investigator (PCI))

Project: Research

Status	Finished
Effective start/end date	1/01/19 → 31/12/21

Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2
Mucha, M. (Leading Author), Lai, Z. (Leading Author), McKenzie, N. J. (Leading Author), Matrà, F. (Leading Author), Boudes, M., Flanigan, S. F., Alejo-Vinogradova, M. T., Monger, C., Zhang, Q., Nimmo, D., Healy, E., Silva, A. J., Angelov, D., Reck, D. M., Holland, G., Atmaca, Z. E., King, H. E., Hamilton, M., Glancy, E. & Nolan, J. & 5 others, Weatheritt, R. J., Bell, O., Vermeulen, M., Davidovich, C. (Leading Author) & Bracken, A. P. (Leading Author), Dec 2025, In: The EMBO Journal. 44, 24, p. 6979–7020 42 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates
Uckelmann, M., Levina, V., Taveneau, C., Ng, X. H., Pandey, V., Martinez, J., Mendiratta, S., Houx, J., Boudes, M., Venugopal, H., Trépout, S., Fulcher, A. J., Zhang, Q., Flanigan, S., Li, M., Sierecki, E., Gambin, Y., Das, P. P., Bell, O. & de Marco, A. & 1 others, Davidovich, C., 2025, In: Nature Structural & Molecular Biology. 32, 3, 32 p., eaba8811.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

8 Link opens in a new tab Citations (Scopus)
Modular Cloning of Multigene Vectors for the Baculovirus System and Yeast
Lai, Z. (Leading Author), Flanigan, S. F., Boudes, M. (Leading Author) & Davidovich, C. (Leading Author), 1 Apr 2025, In: Journal of Molecular Biology. 437, 7, 18 p., 168943.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

5 Link opens in a new tab Citations (Scopus)

FlowCore (FLOW)
Fryga, A. (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
High-performance Computing (M3/MASSIVE)
Powell, D. (Manager) & Tan, G. (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)
Facility/equipment: Facility
Monash Centre for Electron Microscopy (MCEM)
Sorrell, F. (Manager) & Miller, P. (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)
Facility/equipment: Facility

RNA-mediated regulation of the histone methyltransferase PRC2: a new link to disease-associated and causing mutations

Project Details

Research output

Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2

Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates

Modular Cloning of Multigene Vectors for the Baculovirus System and Yeast

Equipment

FlowCore (FLOW)

High-performance Computing (M3/MASSIVE)

Monash Centre for Electron Microscopy (MCEM)