Reducible complexity in the molecular machines of humans and bacteria

  • Lithgow, Trevor (Primary Chief Investigator (PCI))

Project: Research

Project Details

Project Description

Human cells have within with them small, membrane-bound structures called mitchondria which are thought to have evolved from internalised bacteria. We recently developed innovative computer-based methods that can be used to find relationships in protein sequences, and have used these methods to search through sequences of various classes of bacteria, discovering relationships between key bacterial and mitochondrial proteins. We will use a combination of bacterial genetics, structural biology, biochemistry and immunological techniques to fully characterise the location and function of these proteins. We will use a combination of bacterial genetics, structural biology, biochemistry and immunological techniques to fully characterise the location and function of these proteins. This fundamental knowledge will provide an understanding of how human cell mitochondria were created.
StatusFinished
Effective start/end date2/01/0831/12/10

Funding

  • Australian Research Council (ARC): AUD381,180.00