Rational Co-targeting of G protein-coupled receptors as a novel approach towards treating neuropsychiatric disorders

Project: Research

Status	Finished
Effective start/end date	1/01/13 → 31/12/15

Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D₂ Receptor
Lim, H. D., Bartuzi, D., Keen, A. C., Rauffenbart, C., Glenn, J., Charlton, S. J., Lovera, S., Sands, Z. A., Ates, A., Wood, M., Canals, M., Javitch, J. A., Carlsson, J. & Lane, J. R., 18 Jun 2025, In: ACS Chemical Neuroscience. 16, 12, p. 2295–2311 17 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

3 Link opens in a new tab Citations (Scopus)
OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gα_z
Keen, A. C., Pedersen, M. H., Lemel, L., Scott, D. J., Canals, M., Littler, D. R., Beddoe, T., Ono, Y., Shi, L., Inoue, A., Javitch, J. A. & Lane, J. R., Dec 2022, In: Communications Biology. 5, 1, 10 p., 256.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

12 Link opens in a new tab Citations (Scopus)
Structural Features of Iperoxo-BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy
Wakeham, M. C. L., Davie, B. J., Chalmers, D. K., Christopoulos, A., Capuano, B., Valant, C. & Scammells, P. J., 5 Jan 2022, In: ACS Chemical Neuroscience. 13, 1, p. 97-111 15 p.
Research output: Contribution to journal › Article › Research › peer-review

6 Link opens in a new tab Citations (Scopus)

Project Details