| Status | Finished |
|---|---|
| Effective start/end date | 1/01/13 → 31/12/15 |
Funding
- National Health & Medical Research Council (NHMRC): AUD598,987.35
- National Health & Medical Research Council (NHMRC)
Related content
Research Output
Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor
Research output: Contribution to journal › Article › Research › peer-review
The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions
Research output: Contribution to journal › Article › Research › peer-review
Subtle modifications to the indole-2-carboxamide motif of the negative allosteric modulator N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) yield dramatic changes in pharmacological activity at the dopamine D2 receptor
Research output: Contribution to journal › Article › Research › peer-review
Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D 2 receptor
Research output: Contribution to journal › Article › Research › peer-review
Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors
Research output: Contribution to journal › Article › Research › peer-review
Structure-activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor
Research output: Contribution to journal › Article › Research › peer-review
A structure-activity relationship study of the positive allosteric modulator LY2033298 at the M4 muscarinic acetylcholine receptor
Research output: Contribution to journal › Article › Research › peer-review
A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor
Research output: Contribution to journal › Article › Research › peer-review
Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole
Research output: Contribution to journal › Article › Research › peer-review
The role of kinetic context in apparent biased agonism at GPCRs
Research output: Contribution to journal › Article › Research › peer-review
The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor
Research output: Contribution to journal › Article › Research › peer-review
4-phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor
Research output: Contribution to journal › Article › Research › peer-review