Rational Co-targeting of G protein-coupled receptors as a novel approach towards treating neuropsychiatric disorders

Lane, Robert, (Primary Chief Investigator (PCI))
Capuano, Ben (Chief Investigator (CI))
Malone, Daniel (Chief Investigator (CI))

Project: Research

Status	Finished
Effective start/end date	1/01/13 → 31/12/15

Funding

National Health & Medical Research Council (NHMRC): AUD598,987.35
National Health & Medical Research Council (NHMRC)

Related content

Research Output

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

Research output: Contribution to journal › Article › Research › peer-review

A structure-activity relationship study of the positive allosteric modulator LY2033298 at the M₄ muscarinic acetylcholine receptor

Research output: Contribution to journal › Article › Research › peer-review

The role of kinetic context in apparent biased agonism at GPCRs

Research output: Contribution to journal › Article › Research › peer-review

Structure-activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor

Research output: Contribution to journal › Article › Research › peer-review

Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors

Research output: Contribution to journal › Article › Research › peer-review

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D₂ receptor

Research output: Contribution to journal › Article › Research › peer-review

The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions

Research output: Contribution to journal › Article › Research › peer-review

Subtle modifications to the indole-2-carboxamide motif of the negative allosteric modulator N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) yield dramatic changes in pharmacological activity at the dopamine D₂ receptor

Research output: Contribution to journal › Article › Research › peer-review

Novel fused arylpyrimidinone based allosteric modulators of the M₁ muscarinic acetylcholine receptor

Research output: Contribution to journal › Article › Research › peer-review

4-phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M₁ muscarinic acetylcholine receptor

Research output: Contribution to journal › Article › Research › peer-review