Rational Co-targeting of G protein-coupled receptors as a novel approach towards treating neuropsychiatric disorders

Lane, Robert (Primary Chief Investigator (PCI))
Capuano, Ben (Chief Investigator (CI))
Malone, Daniel (Chief Investigator (CI))

Project: Research

Status	Finished
Effective start/end date	1/01/13 → 31/12/15

Funding

National Health and Medical Research Council (NHMRC) (Australia): A$598,987.35

14 Article

Structural Features of Iperoxo-BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy
Wakeham, M. C. L., Davie, B. J., Chalmers, D. K., Christopoulos, A., Capuano, B., Valant, C. & Scammells, P. J., 5 Jan 2022, In: ACS Chemical Neuroscience. 13, 1, p. 97-111 15 p.
Research output: Contribution to journal › Article › Research › peer-review
Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M₁ Muscarinic Acetylcholine Receptor
Jörg, M., Khajehali, E., van der Westhuizen, E. T., C. Choy, K. H., Shackleford, D. M., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 8 Jan 2021, In: ChemMedChem. 16, 1, p. 216-233 18 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

1 Citation (Scopus)
A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor
Fyfe, T. J., Zarzycka, B., Lim, H. D., Kellam, B., Mistry, S. N., Katrich, V., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Oct 2019, In: Journal of Medicinal Chemistry. 62, 1, p. 174-206 33 p.
Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)