Rational Co-targeting of G protein-coupled receptors as a novel approach towards treating neuropsychiatric disorders

Project: Research

Status	Finished
Effective start/end date	1/01/13 → 31/12/15

OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gα_z
Keen, A. C., Pedersen, M. H., Lemel, L., Scott, D. J., Canals, M., Littler, D. R., Beddoe, T., Ono, Y., Shi, L., Inoue, A., Javitch, J. A. & Lane, J. R., Dec 2022, In: Communications Biology. 5, 1, 10 p., 256.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

8 Citations (Scopus)
Structural Features of Iperoxo-BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy
Wakeham, M. C. L., Davie, B. J., Chalmers, D. K., Christopoulos, A., Capuano, B., Valant, C. & Scammells, P. J., 5 Jan 2022, In: ACS Chemical Neuroscience. 13, 1, p. 97-111 15 p.
Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)
Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M₁ Muscarinic Acetylcholine Receptor
Jörg, M., Khajehali, E., van der Westhuizen, E. T., C. Choy, K. H., Shackleford, D. M., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 8 Jan 2021, In: ChemMedChem. 16, 1, p. 216-233 18 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

6 Citations (Scopus)

Project Details