Raman and synchrotron spectroscopy of nano-scale drug interactions and molecular processes in single living cells

  • Wood, Bayden (Primary Chief Investigator (PCI))
  • McNaughton, Donald (Chief Investigator (CI))
  • Robertson, Evan Garry, (Chief Investigator (CI))
  • Ozaki, Yukihiro (Partner Investigator (PI))
  • Tait, Brian D. (Partner Investigator (PI))

Project: Research

Project Description

The ability to detect drug uptake and simultaneously monitor the molecular environment in single living cells is paramount to streamlining drug screening programs. We have developed vibrational spectroscopic methods to non-destructively probe the molecular architecture of single living functional cells. More recently we applied the brilliance of IR synchrotron light to resolve macromolecular information from sub cellular components in response to drug therapy. We plan to further develop these methods and combine them with spectral enhancement techniques to develop new drug screening protocols. These studies will provide a fundamental molecular basis to understanding the nano-scale drug interactions in living cells.
StatusFinished
Effective start/end date3/01/0631/12/08

Funding

  • Australian Research Council (ARC): AUD90,000.00
  • Australian Research Council (ARC): AUD200,000.00
  • Monash University: AUD201,000.00