This project examines new regulatory mechanisms for an important signaling enzyme in the cell nucleus. It aims to define how this enzyme enters the nucleus, to characterize new modifications that impact its actions, and to establish how a conserved nuclear protein may provide an unexpected regulatory platform to send nucleusinitiated signals back to the cell cytoplasm. This reverse signaling is a novel mechanism for integrating nuclear actions that has the potential to create a signal transduction circuit triggered by environmental or genetic factors. This information is crucial in defining the molecular logic of signaling events that may be ultimately targeted to control cell growth, differentiation and survival.
|Effective start/end date||1/01/16 → 31/12/18|
- Australian Research Council (ARC): AUD60,000.00