Protein Kinase Regulatory Switches: Decision-Making in the Nucleus

  • Jans, David (Primary Chief Investigator (PCI))

Project: Research

Project Details

Project Description

This project examines new regulatory mechanisms for an important signaling enzyme in the cell nucleus. It aims
to define how this enzyme enters the nucleus, to characterize new modifications that impact its actions, and to
establish how a conserved nuclear protein may provide an unexpected regulatory platform to send nucleusinitiated
signals back to the cell cytoplasm. This reverse signaling is a novel mechanism for integrating nuclear
actions that has the potential to create a signal transduction circuit triggered by environmental or genetic factors.
This information is crucial in defining the molecular logic of signaling events that may be ultimately targeted to
control cell growth, differentiation and survival.
Effective start/end date1/01/1631/12/18


  • Australian Research Council (ARC): A$60,000.00