Probing the role of dynamics in protein modulation of GPCR phenotype

Project: Research

Status	Finished
Effective start/end date	1/06/21 → 31/12/23

Conformational Dynamics of Amylin Receptors Revealed by Hydrogen–Deuterium Exchange Mass Spectrometry
Fairweather, C. J., Zhang, X., Fernando, C. D., Garama, D. J., Sexton, P. M., Wootten, D. & Josephs, T. M., 29 Apr 2026, In: Journal of the American Chemical Society. 148, 16, p. 16702-16712 11 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

1 Link opens in a new tab Citation (Scopus)
Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors
Cao, J., Belousoff, M. J., Johnson, R. M., Keov, P., Mariam, Z., Deganutti, G., Christopoulos, G., Hick, C. A., Reedtz-Runge, S., Glendorf, T., Ballarín-González, B., Raun, K., Bayly-Jones, C., Wootten, D. & Sexton, P. M., 10 Apr 2025, In: Nature Communications. 16, 1, 15 p., 3389.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

16 Link opens in a new tab Citations (Scopus)
Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein
Cao, J., Belousoff, M. J., Danev, R., Christopoulos, A., Wootten, D. & Sexton, P. M., 7 May 2024, In: Biochemistry. 63, 9, p. 1089-1096 8 p.
Research output: Contribution to journal › Article › Research › peer-review

10 Link opens in a new tab Citations (Scopus)

Project Details