Pre-clinical evaluation of selective adenosine A1 receptor positive allosteric modulators for the treatment of drug-resistant epilepsy

Kwan, Patrick (Primary Chief Investigator (PCI))
May, Lauren (Chief Investigator (CI))
Rollo, Ben (Chief Investigator (CI))
O'Brien, Terence (Chief Investigator (CI))
Casillas-Espinosa, Pablo (Chief Investigator (CI))
Howden, Sarah (Chief Investigator (CI))
Christopoulos, Arthur (Chief Investigator (CI))
Gregory, Karen (Chief Investigator (CI))
Scammells, Peter (Chief Investigator (CI))
Baltos, Jo-Anne (Chief Investigator (CI))
Elliott, David (Chief Investigator (CI))
TN Nguyen, Anh (Chief Investigator (CI))
Langmead, Christopher (Chief Investigator (CI))
Antonic-Baker, Ana (Chief Investigator (CI))
Sumer, Huseyin (Chief Investigator (CI))
Javaid, Shahid (Associate Investigator (AI))
Gu, Jinchao (Chief Investigator (CI))

Project: Research

Status	Active
Effective start/end date	1/06/22 → 31/05/27

4 Article
1 Review Article

Ngn2-Induced Differentiation of the NG108-15 Cell Line Enhances Motor Neuronal Differentiation and Neuromuscular Junction Formation
Meli, M., Swiderski, K., Gu, J., Rollo, B., Bartlett, B., Caldow, M. K., Lynch, G. S., Kwan, P., Sumer, H. & Cromer, B., May 2025, In: Biomolecules. 15, 5, 24 p., 637.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

1 Citation (Scopus)
Structure-based discovery of positive allosteric modulators of the A₁ adenosine receptor
Nguyen, A. T. N., Panel, N., Vo, D. D., Thai, B. S., Chia, L. Y., Lu, C. S., Hellyer, S. D., Langiu, M., Jörg, M., Gregory, K. J., Kihlberg, J., White, P. J., Scammells, P. J., Christopoulos, A., Carlsson, J. & May, L. T., 15 Jul 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 28, 10 p., e2421687122.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

2 Citations (Scopus)
Transmembrane α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor regulatory protein expression during the development of absence seizures in genetic absence epilepsy rats from Strasbourg
Casillas-Espinosa, P. M., Lin, R., Li, R., Powell, K. L. & O'Brien, T. J., Feb 2024, In: Epilepsia. 65, 2, p. e20-e26 7 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

1 Citation (Scopus)

Centre for Drug Candidate Optimisation (CDCO)
Charman, S. (Other)
Pharmacy and Pharmaceutical Sciences Faculty Office
Facility/equipment: Facility
Monash Animal Research Platform (MARP)
Findlay, C. (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
Monash Biomedical Imaging (MBI)
Reid, K. (Manager), Brkljaca, R. (Manager), Hagemeyer, C. (Other) & Wright, D. (Other)
Office of the Vice-Provost (Research and Research Infrastructure)
Facility/equipment: Facility