Research output per year
Research output per year
Project Details
Project Description
Deciphering the multi-layered regulation of cell fate decisions is challenging. While progress has been made
in understanding the role of transcriptional regulation, the influence of post-translational modification is
poorly understood. We have shown that NEDD4-mediated ubiquitination is absolute necessary for sex
determination, a unique model of cell fate decision where gonadal cell precursors differentiate either along
the male or the female pathway. We will now analyse in detail at which stage NEDD4 action is required and
what are the crucial target proteins. This project will provide a deeper understanding of how posttranslational
modifications influence cell fate decisions during embryogenesis
in understanding the role of transcriptional regulation, the influence of post-translational modification is
poorly understood. We have shown that NEDD4-mediated ubiquitination is absolute necessary for sex
determination, a unique model of cell fate decision where gonadal cell precursors differentiate either along
the male or the female pathway. We will now analyse in detail at which stage NEDD4 action is required and
what are the crucial target proteins. This project will provide a deeper understanding of how posttranslational
modifications influence cell fate decisions during embryogenesis
| Status | Finished |
|---|---|
| Effective start/end date | 1/01/15 → 31/12/17 |
Funding
- Australian Research Council (ARC): A$515,300.00
- Monash University
- University of South Australia
Research output
- 1 Article
-
Heterozygous deletion of Sox9 in mouse mimics the gonadal sex reversal phenotype associated with campomelic dysplasia in humans
Bagheri-Fam, S., Combes, A. N., Ling, C. K. & Wilhelm, D., 1 Dec 2021, In: Human Molecular Genetics. 29, 23, p. 3781-3792 12 p.Research output: Contribution to journal › Article › Research › peer-review
6 Citations (Scopus)