Post-translational control of cell fate decision

  • Wilhelm, Dagmar (Primary Chief Investigator (PCI))
  • Kumar, Sharad (Chief Investigator (CI))

Project: Research

Project Details

Project Description

Deciphering the multi-layered regulation of cell fate decisions is challenging. While progress has been made
in understanding the role of transcriptional regulation, the influence of post-translational modification is
poorly understood. We have shown that NEDD4-mediated ubiquitination is absolute necessary for sex
determination, a unique model of cell fate decision where gonadal cell precursors differentiate either along
the male or the female pathway. We will now analyse in detail at which stage NEDD4 action is required and
what are the crucial target proteins. This project will provide a deeper understanding of how posttranslational
modifications influence cell fate decisions during embryogenesis
Effective start/end date1/01/1531/12/17


  • Australian Research Council (ARC): A$515,300.00
  • Monash University
  • University of South Australia