Positive allosteric modulation of metabotropic glutamate receptor 5; a novel approach for the treatment of schizophrenia and cognitive disorders

Gregory, Karen (Primary Chief Investigator (PCI))

Pharmacology

Project: Research

Status	Finished
Effective start/end date	1/01/11 → 31/12/15

Funding

National Health and Medical Research Council (NHMRC) (Australia): A$169,060.00
National Health and Medical Research Council (NHMRC) (Australia): A$169,060.00

10 Article
1 Short Survey

Differential contribution of metabotropic glutamate receptor 5 common allosteric binding site residues to biased allosteric agonism
Sengmany, K., Hellyer, S. D., Christopoulos, A., Lapinsky, D. J., Leach, K. & Gregory, K. J., Jul 2020, In: Biochemical Pharmacology. 177, 15 p., 114011.
Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)
Probe dependence and biased potentiation of metabotropic glutamate receptor 5 is mediated by differential ligand interactions in the common allosteric binding site
Hellyer, S. D., Sengmany, K., Keller, A. N., Christopoulos, A., Leach, K. & Gregory, K. J., Jul 2020, In: Biochemical Pharmacology. 177, 20 p., 114013.
Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)
Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology
Sengmany, K., Hellyer, S. D., Albold, S., Wang, T., Conn, P. J., May, L. T., Christopoulos, A., Leach, K. & Gregory, K. J., 1 May 2019, In: Neuropharmacology. 149, p. 83-96 14 p.
Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)