Positive allosteric modulation of anti-convulsant G protein-coupled receptor signalling to treat drug-resistant epilepsy

May, Lauren (Primary Chief Investigator (PCI))
Webb, Geoff (Chief Investigator (CI))
Carlsson, Jens (Chief Investigator (CI))
Baltos, Jo-Anne (Chief Investigator (CI))
TN Nguyen, Anh (Chief Investigator (CI))
Christopoulos, Arthur (Associate Investigator (AI))
Miao, Yinglong (Associate Investigator (AI))
O'Brien, Terence (Associate Investigator (AI))
Rollo, Ben (Associate Investigator (AI))
Casillas-Espinosa, Pablo (Associate Investigator (AI))
Gregory, Karen (Associate Investigator (AI))
Scammells, Peter (Associate Investigator (AI))
Nguyen, Toan (Associate Investigator (AI))

Project: Research

Status	Active
Effective start/end date	1/01/22 → 31/12/26

8 Review Article
6 Article

Chronic behavioral and seizure outcomes following experimental traumatic brain injury and comorbid Klebsiella pneumoniae lung infection in mice
Rewell, S. S. J., Shad, A., Chen, L., Chu, E., Wang, J., Chen, K., O'Brien, T. J., Li, J., Casillas Espinosa, P. M. & Semple, B. D., Nov 2025, In: Epilepsia. 66, 11, p. 4513–4524 12 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
Dissociation kinetics of G proteins from G protein–coupled receptors and effects of allosteric modulation
Wang, J., Nguyen, A. T. N., Adediwura, V. A., Lu, C. S., McNeill, S. M., Jörg, M., Scammells, P. J., Christopoulos, A., May, L. T. & Miao, Y., 18 Nov 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 46, 9 p., e2512423122.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

4 Link opens in a new tab Citations (Scopus)
Structure-based discovery of positive allosteric modulators of the A₁ adenosine receptor
Nguyen, A. T. N., Panel, N., Vo, D. D., Thai, B. S., Chia, L. Y., Lu, C. S., Hellyer, S. D., Langiu, M., Jörg, M., Gregory, K. J., Kihlberg, J., White, P. J., Scammells, P. J., Christopoulos, A., Carlsson, J. & May, L. T., 15 Jul 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 28, 10 p., e2421687122.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

7 Link opens in a new tab Citations (Scopus)

High-performance Computing (M3/MASSIVE)
Powell, D. (Manager) & Tan, G. (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)
Facility/equipment: Facility
Monash Biomedical Imaging (MBI)
Reid, K. (Manager), Brkljaca, R. (Manager), Hagemeyer, C. (Other) & Wright, D. (Other)
Office of the Vice-Provost (Research and Research Infrastructure)
Facility/equipment: Facility

Positive allosteric modulation of anti-convulsant G protein-coupled receptor signalling to treat drug-resistant epilepsy

Project Details

Chronic behavioral and seizure outcomes following experimental traumatic brain injury and comorbid Klebsiella pneumoniae lung infection in mice

Dissociation kinetics of G proteins from G protein–coupled receptors and effects of allosteric modulation

Structure-based discovery of positive allosteric modulators of the A₁ adenosine receptor

High-performance Computing (M3/MASSIVE)

Monash Biomedical Imaging (MBI)

Positive allosteric modulation of anti-convulsant G protein-coupled receptor signalling to treat drug-resistant epilepsy

Project Details

Research output

Chronic behavioral and seizure outcomes following experimental traumatic brain injury and comorbid Klebsiella pneumoniae lung infection in mice

Dissociation kinetics of G proteins from G protein–coupled receptors and effects of allosteric modulation

Structure-based discovery of positive allosteric modulators of the A1 adenosine receptor

Equipment

High-performance Computing (M3/MASSIVE)

Monash Biomedical Imaging (MBI)

Structure-based discovery of positive allosteric modulators of the A₁ adenosine receptor