Phosphatases in the pathogenesis of obesity and cancer

Tiganis, Tony (Primary Chief Investigator (PCI))

Biochemistry & Molecular Biology

Project: Research

Status	Active
Effective start/end date	1/01/22 → 31/12/26

Keywords

protein tyrosine phosphatase (PTP)
insulin signalling
immunotherapy
liver cancer
obesity

2 Article

Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity
Greatorex, S., Kaur, S., Xirouchaki, C. E., Goh, P. K., Wiede, F., Genders, A. J., Tran, M., Jia, Y. Y., Raajendiran, A., Brown, W. A., McLean, C. A., Sadoshima, J., Watt, M. J. & Tiganis, T., Feb 2024, In: Journal of Clinical Investigation. 134, 3, 24 p., e162533.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

17 Citations (Scopus)
MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention
Qiu, B., Lawan, A., Xirouchaki, C. E., Yi, J-S., Robert, M., Zhang, L., Brown, W., Fernández-Hernando, C., Yang, X., Tiganis, T. & Bennett, A. M., Dec 2023, In: Nature Communications. 14, 1, 19 p., 5405.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

8 Citations (Scopus)

Animal Research Platform (MARP)
Christine Findlay (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
FlowCore
Andrew Fryga (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
Histology Platform
Camilla Cohen (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility