Orchestrating cellular processes by engineering Si nanowire architectures

The aim is to address primary challenges for gene transport by creating low-cost, easily implemented, programmable and controllable Si nanowire-mediated transfection technology; and to demonstrate high-throughput, parallel trafficking of bioactive payloads. Success would enable the design and fabrication of novel nano–bio interfaces with closely controlled geometry and architecture, to orchestrate specific cellular processes such as cellular reprogramming, adhesion, morphology, and differentiation with unprecedented efficiency and predictability. The advance would unlock potential for major breakthroughs in fundamental cellular studies, enabling better understanding of the parameters that govern cell behaviour, function and fate.