Optimisation of peptidic non-phosphorylated inhibitors of the Grb7 SH2 domain

  • Wilce, Jackie (Primary Chief Investigator (PCI))
  • Krag, David (Partner Investigator (PI))

Project: Research

Project Details

Project Description

The Grb7 protein plays a role in regulating cell growth and spread. It is overproduced in many types of cancer cells and is implicated in aggressive forms of cancer cell growth and spread. The current proposal is to optimise peptide-based inhibitor molecules that can block its action. Potent and specific peptides that inhibit cancer cell progression would represent proof of concept for the development of a new Grb7-based anti-cancer drug therapy
StatusFinished
Effective start/end date5/01/0931/12/11

Funding

  • Australian Research Council (ARC): AUD420,000.00
  • Australian Research Council (ARC)