Optimisation by Platform Trial Involving Multiple Interventions with Simultaneous Evaluation in Community Acquired Pneumonia (OPTIMISE-CAP)

Webb, Steven (Primary Chief Investigator (PCI))
Berry, Donald (Chief Investigator (CI))
Cheng, Allen (Chief Investigator (CI))
Heritier, Stephane (Chief Investigator (CI))
Litton, Edward (Chief Investigator (CI))
McArthur, Colin (Chief Investigator (CI))
Paterson, David L. (Chief Investigator (CI))
Presneill, Jeffrey (Chief Investigator (CI))

Project: Research

Status	Finished
Effective start/end date	1/01/16 → 31/12/22

Funding

National Health and Medical Research Council (NHMRC) (Australia): A$4,413,145.20

10 Article

Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized with COVID-19: A Randomized Clinical Trial
REMAP-CAP Writing Committee for the REMAP-CAP Investigators, 11 Apr 2023, In: JAMA. 329, 14, p. 1183-1196 14 p.
Research output: Contribution to journal › Article › Research › peer-review

49 Citations (Scopus)
Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials
Adhikari, N. K. J., Hashmi, M., Tirupakuzhi Vijayaraghavan, B. K., Haniffa, R., Beane, A., Webb, S. A., Angus, D. C., Gordon, A. C., Cook, D. J., Guyatt, G. H., Berry, L. R., Lorenzi, E., Mouncey, P. R., Au, C., Pinto, R., Ménard, J., Sprague, S., Masse, M. H., Huang, D. T. & Heyland, D. K. & 64 others, Nichol, A. D., McArthur, C. J., de Man, A., Al-Beidh, F., Annane, D., Anstey, M., Arabi, Y. M., Battista, M. C., Berry, S., Bhimani, Z., Bonten, M. J. M., Bradbury, C. A., Brant, E. B., Brunkhorst, F. M., Burrell, A., Buxton, M., Cecconi, M., Cheng, A. C., Cohen, D., Cove, M. E., Day, A. G., Derde, L. P. G., Detry, M. A., Estcourt, L. J., Fagbodun, E. O., Fitzgerald, M., Goossens, H., Green, C., Higgins, A. M., Hills, T. E., Ichihara, N., Jayakumar, D., Kanji, S., Khoso, M. N., Lawler, P. R., Lewis, R. J., Litton, E., Marshall, J. C., McAuley, D. F., McGlothlin, A., McGuinness, S. P., McQuilten, Z. K., McVerry, B. J., Murthy, S., Parke, R. L., Parker, J. C., Reyes, L. F., Rowan, K. M., Saito, H., Salahuddin, N., Santos, M. S., Saunders, C. T., Seymour, C. W., Shankar-Hari, M., Tolppa, T., Trapani, T., Turgeon, A. F., Turner, A. M., Udy, A. A., van de Veerdonk, F. L., Zarychanski, R., Lamontagne, F., The LOVIT-COVID Investigators & on behalf of the Canadian Critical Care Trials Group and the REMAP-CAP Investigators, 14 Nov 2023, In: JAMA. 330, 18, p. 1745-1759 15 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

27 Citations (Scopus)
Long-term (180-Day) Outcomes in Critically Ill Patients with COVID-19 in the REMAP-CAP Randomized Clinical Trial
The Writing Committee for the REMAP-CAP Investigators, 3 Jan 2023, In: JAMA. 329, 1, p. 39-51 13 p.
Research output: Contribution to journal › Article › Research › peer-review

93 Citations (Scopus)

HELIX (Sensitive Data Platform)
Powell, D. (Manager) & Andreou, V. (Other)
Office of the Vice-Provost (Research and Research Infrastructure)
Facility/equipment: Facility

Optimisation by Platform Trial Involving Multiple Interventions with Simultaneous Evaluation in Community Acquired Pneumonia (OPTIMISE-CAP)

Project Details

Funding

Research output

Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized with COVID-19: A Randomized Clinical Trial

Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials

Long-term (180-Day) Outcomes in Critically Ill Patients with COVID-19 in the REMAP-CAP Randomized Clinical Trial

Equipment

HELIX (Sensitive Data Platform)