Nox isoforms and chemokine receptors as therapeutic targets in vascular disease and stroke

Research output

Research output per year 2014 2014 2015 2019

• 20 Article

Research output per year

Research output per year

Search results

• 2019

  Distinct Redox Signalling following Macrophage Activation Influences Profibrotic Activity

  Lewis, C. V., Vinh, A., Diep, H., Samuel, C. S., Drummond, G. R. & Kemp-Harper, B. K., 11 Nov 2019, In: Journal of Immunology Research. 2019, 15 p., 1278301.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  10 Citations (Scopus)

• Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

  Krishnan, S. M., Ling, Y. H., Huuskes, B. M., Ferens, D. M., Saini, N., Chan, C. T., Diep, H., Kett, M. M., Samuel, C. S., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Peter, K., Latz, E., Mansell, A. S., Sobey, C. G., Drummond, G. R. & Vinh, A., 15 Mar 2019, In: Cardiovascular Research. 115, 4, p. 776-787 12 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  193 Citations (Scopus)
• 2018

  NOX2 oxidase expressed in endosomes promotes cell proliferation and prostate tumour development

  Harrison, I. P., Vinh, A., Johnson, I. R. D., Luong, R., Drummond, G. R., Sobey, C. G., Tiganis, T., Williams, E. D., O'Leary, J., Brooks, D. A. & Selemidis, S., 23 Oct 2018, In: Oncotarget. 9, 83, p. 35378-35393 16 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  22 Citations (Scopus)
• 2017

  Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension

  Ling, Y. H., Krishnan, S. M., Chan, C. T., Diep, H., Ferens, D., Chin-Dusting, J., Kemp-Harper, B. K., Samuel, C. S., Hewitson, T. D., Latz, E., Mansell, A., Sobey, C. G. & Drummond, G. R., Feb 2017, In: Pharmacological Research. 116, p. 77-86 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  43 Citations (Scopus)

• Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

  To, E. E., Vlahos, R., Luong, R., Halls, M. L., Reading, P. C., King, P. T., Chan, C., Drummond, G. R., Sobey, C. G., Broughton, B. R. S., Starkey, M. R., van der Sluis, R., Lewin, S. R., Bozinovski, S., O'Neill, L. A. J., Quach, T., Porter, C. J. H., Brooks, D. A., O'Leary, J. & Selemidis, S., 1 Dec 2017, In: Nature Communications. 8, 1, 17 p., 69.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  115 Citations (Scopus)
• 2016

  Evidence of CCR2-independent transmigration of Ly6C^hi monocytes into the brain after permanent cerebral ischemia in mice

  Chu, H. X., Kim, H. A., Lee, S., Broughton, B. R. S., Drummond, G. R. & Sobey, C. G., 15 Apr 2016, In: Brain Research. 1637, p. 118-127 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  17 Citations (Scopus)

• Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice

  Krishnan, S. M., Dowling, J. K., Ling, Y. H., Diep, H., Chan, C. T., Ferens, D., Kett, M. M., Pinar, A., Samuel, C. S., Vinh, A., Arumugam, T. V., Hewitson, T. D., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Latz, E., Mansell, A., Sobey, C. G. & Drummond, G. R., 1 Feb 2016, In: British Journal of Pharmacology. 173, 4, p. 752-765 14 p.

  Research output: Contribution to journal › Article › Research › peer-review
  154 Citations (Scopus)
• 2015

  Effect of a selective mas receptor agonist in cerebral ischemia in vitro and in vivo

  Lee, S. S., Evans, M. A., Chu, H. X., Kim, H. H. A., Widdop, R. E., Drummond, G. R. & Sobey, C. G., 2015, In: PLoS ONE. 10, 11, 11 p., e0142087.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

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  27 Citations (Scopus)

• Evidence that Ly6C(hi) monocytes are protective in acute ischemic stroke by promoting M2 macrophage polarization

  Chu, H. X., Broughton, B. R. S., Kim, H. H. A., Lee, S. S., Drummond, G. R. & Sobey, C. G., 2015, In: Stroke. 46, 7, p. 1929 - 1937 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  122 Citations (Scopus)

• Ghrelin-related peptides exert protective effects in the cerebral circulation of male mice through a nonclassical ghrelin receptor(s)

  Ku, J., Andrews, Z. B., Barsby, T., Reichenbach, A., Lemus, M. B., Drummond, G. R., Sleeman, M., Spencer, S. J., Sobey, C. G. & Miller, A. A., 2015, In: Endocrinology. 156, 1, p. 280 - 290 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  27 Citations (Scopus)

• M2 macrophage accumulation in the aortic wall during angiotensin II infusion in mice is associated with fibrosis, elastin loss, and elevated blood pressure

  Moore, J. P., Vinh, A., Tuck, K. L., Sakkal, S., Krishnan, S., Chan, C., Lieu, M., Samuel, C. S., Diep, H., Harper, B. K., Tare, M., Ricardo, S. D., Guzik, T. J., Sobey, C. G. & Drummond, G. R., 2015, In: American Journal of Physiology - Heart and Circulatory Physiology. 309, 5, p. 906 - 917 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  116 Citations (Scopus)

• NOX1 deficiency in apolipoprotein E-knockout mice is associated with elevated plasma lipids and enhanced atherosclerosis

  Sobey, C. G., Judkins, C. P., Rivera, J., Lewis, C., Diep, H., Lee, H. W., Kemp-Harper, B. K., Broughton, B. R. S., Selemidis, S., Gaspari, T. A., Samuel, C. S. & Drummond, G. R., 2015, In: Free Radical Research. 49, 2, p. 186 - 198 13 p.

  Research output: Contribution to journal › Article › Research › peer-review
  30 Citations (Scopus)

• Obligatory role for B cells in the development of angiotensin II-dependent hypertension

  Chan, C. T-L., Sobey, C. G., Lieu, M., Ferens, D. M., Kett, M. M., Diep, H., Kim, H. H. A., Krishnan, S. M., Lewis, C. V., Salimova, E., Tipping, P. G., Vinh, A., Samuel, C. S., Peter, K., Guzik, T. J., Kyaw, T. S., Toh, B-H., Bobik, A. & Drummond, G. R., 2015, In: Hypertension. 66, 5, p. 1023 - 1033 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  191 Citations (Scopus)

• Risk of major cardiovascular events in people with down syndrome

  Sobey, C. G., Judkins, C. P., Sundararajan, V., Phan, T. G., Drummond, G. R. & Srikanth, V. K., 2015, In: PLoS ONE. 10, 9, 11 p., e0137093.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  105 Citations (Scopus)
• 2014

  Antibodies in the pathogenesis of hypertension

  Chan, C., Lieu, M., Toh, B-H., Kyaw, T. S., Bobik, A., Sobey, C. G. & Drummond, G. R., 2014, In: BioMed Research International. 2014, (Art. No: 504045), p. 1 - 9 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  32 Citations (Scopus)

• Brain immune cell composition and functional outcome after cerebral ischemia: comparison of two mouse strains

  Kim, H. A., Whittle, S., Lee, S. S., Chu, H., Zhang, S., Wei, Z., Arumugam, T., Vinh, A., Drummond, G. R. & Sobey, C. G., 2014, In: Frontiers in Cellular Neuroscience. 8, 365, 12 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File

• Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation

  Chrissobolis, S., Drummond, G. R., Faraci, F. M. & Sobey, C. G., 2014, In: Journal of Hypertension. 32, 9, p. 1815 - 1821 7 p.

  Research output: Contribution to journal › Article › Research › peer-review
  32 Citations (Scopus)

• Endothelial NADPH oxidases: which NOX to target in vascular disease?

  Drummond, G. R. & Sobey, C. G., 2014, In: Trends in Endocrinology and Metabolism. 25, 9, p. 452 - 463 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  260 Citations (Scopus)

• IL-1beta and IL-18: inflammatory markers or mediators of hypertension?

  Murali Krishnan, S., Sobey, C. G., Latz, E., Mansell, A. S. & Drummond, G. R., 2014, In: British Journal of Pharmacology. 171, 24, p. 5589 - 5602 14 p.

  Research output: Contribution to journal › Article › Research › peer-review
  176 Citations (Scopus)

• Role of CCR2 in inflammatory conditions of the central nervous system

  Chu, H., Arumugam, T., Gelderblom, M., Magnus, T., Drummond, G. R. & Sobey, C. G., 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, 9, p. 1425 - 1429 5 p.

  Research output: Contribution to journal › Article › Research › peer-review
  123 Citations (Scopus)